Course Description: The use and translation of animal models of human disease requires a strong understanding of the anatomy, physiology and pathobiology of each specific model. This presentation will provide an overview highlighting key species differences in the liver, gastrointestinal tract, kidney, reproductive tract, central nervous system, and skin of commonly utilized laboratory animal models including: rodents, genetically-engineered mice, beagle dogs, non-human primates, and the mini-pig; using an organ system approach. A step-wise correlation of gross anatomic, light microscopic (H&E), and ultrastructural morphology will give the attendees an appreciation of the biological complexity as species-related systemic differences are characterized. The presentation will conclude with a discussion on commonly encountered spontaneous “background” lesions in key laboratory animal species (e.g., chronic progressive nephropathy in rodents) as well as several examples of unusual test article-related lesions encountered in non-clinical drug development. The session will provide a solid overview that will allow the attendees to confidently work with these animal models.
Additional Information: This webinar was presented in November 2015 as part of the NSH Veterinary & Research Scientist Webinar Series.